By Sinatra R.S., Ginsberg B., Viscusi E.
This textbook presents an outline of soreness administration helpful to experts in addition to non-specialists, surgeons, and nursing employees.
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Additional info for Acute Pain Management
Opioid responsiveness of cancer pain syndromes caused by neuropathic or nociceptive mechanisms: a combined analysis of controlled, singledose studies. Neurology. 1994;44(5):857–861. 3. Woolf CJ, King AE. Subthreshold components of the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat lumbar spinal cord. J Neurophysiol. 1989;62(4):907–916. 4. Andersson GB. Epidemiological features of chronic low-back pain. Lancet. 1999;354(9178):581–585. 5. Smith BH, Elliott AM, Chambers WA, Smith WC, Hannaford PC, Penny K.
Metabolic changes have been studied with brain chemistry studies in pain states. Grachev et al72 studied the brain chemistry changes in patients with chronic back pain in vivo singlevoxel proton magnetic resonance spectroscopy (H-MRS). The concentration of several substances, including N-acetyl aspartate, creatine, choline, Glut, glutamine, GABA, inositol, glucose, and lactate, was studied. They found direct abnormal brain chemistry in chronic back pain as compared to volunteers that could be useful in the diagnosis and development of effective drugs for the treatment of pain Understanding the variability of the μ-opioid-receptormediated antinociceptive responses and stress responses with functional neuroimaging may offer an important tool to help us understand why individuals respond differently to similar painful stimuli.
Beilin B, Bessler H, Mayburd E, et al. Effects of preemptive analgesia on pain and cytokine production in the postoperative period. Anesthesiology. 2003;98(1):151–155. 44. Beilin B, Shavit Y, Trabekin E, et al. The effects of postoperative pain management on immune response to surgery. Anesth Analges. 2003;97(3):822–827. 45. Winter J, Bevan S, Campbell EA. Capsaicin and pain mechanisms. Br J Anaesth. 1995;75(2):157–168. 46. Djouhri L, Koutsikou S, Fang X, McMullan S, Lawson SN. Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors.