By Alan Ebringer
Ankylosing spondylitis and Klebsiella is a finished and informative textual content at the reason behind Ankylosing spondylitis. Ankylosing spondylitis (AS) is a situation which impacts 20 million humans around the globe and is probably going triggered or initiated by means of a bowel an infection from Klebsiella bacteria.
When a sufferer is contaminated by way of Klebsiella bacteria, his or her immune process will make antibodies opposed to all of the antigens or molecules present in the microbe. simply because a number of the bacterial antigens resemble self tissues, the anti-bacterial antibodies will assault not just the micro organism but additionally the self tissues comparable to the joints and the cells having an identical HLA molecules, that is how the sickness AS starts off. this is often the concept that of molecular similarity or “molecular mimicry” which formerly has been came upon to paintings in different autoimmune illnesses; rheumatic fever and rheumatoid arthritis.
The first paper in this topic was once released in 1976 and because thenover a hundred papers on rheumatological themes were released, from Prof Ebringer’s staff, on the department of lifestyles Sciences, King’s collage in London, united kingdom.
The correct details from those papers is extracted and provided during this ebook structure making it available to wellbeing and fitness pros, study associations, pharmaceutical businesses and universities and most people.
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Additional resources for Ankylosing spondylitis and Klebsiella
Clearly, this is an early sighting of Reiter’s disease. 8 Bechterew in St. Petersburg Vladimir Bechterew (1857–1927) was a neurologist who in 1982 described three patients: a mother and daughter and a man who had sometime in the past incurred some trauma to his back. These were his conclusions: Based on the clinical data we may assume that we are dealing with a chronic process of the vertebrae that develops independently and leads to ankylosis. It also probably leads to a diffuse, chronic inflammation of the epidural connective tissue.
1978;79:865–7. Festenstein H, Démant P. HLA and H-2. London: Edward Arnold; 1978. Hirata AA, McIntire FC, Terasaki PI, Mittal KK. Crossreactions between human transplantation antigens and bacterial lipopolysaccharides. Transplantation. 1973;15:441–5. Kaplan MH, Meyeserian M. An immunological crossreaction between Group A Streptococcal cells and human heart. Lancet. 1962;1:706–10. Rowley D, Jenkin CR. Antigenic crossreaction between host and parasite as a possible cause of pathogenicity. Nature.
James described the work carried out in the ‘Tissue Typing Laboratory’ of the Westminster Hospital. He writes: I recalled many families in my native Wales being affected by rheumatism. Could immunogenetic studies be carried out in such patients. I wrote to the then Consultant Rheumatologist at the Westminster Hospital Dr. Frank Dudley Hart and asked him for some information on HLA and rheumatism. ” Thereupon I contacted his registrar Dr. Roger Sturrock who duly sent an assortment of blood specimens taken at random from rheumatic patients.