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By Brian L. Samuels, John E. Ultmann (auth.), John E. Ultmann, Brian L. Samuels (eds.)

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One clue for an understanding of this dissociation between genotype and phenotype is provided by experiments in which progenitor B cells (without any gene rearrangement) and pre-B cells (rearranged heavy chain genes in the absence of rearranged light chain genes) were infected with EBV in vitro, leading to the establishment of permanent cell lines with the germ-line configuration of Ig and TCR genes, and cell lines with rearranged heavy chain and nonrearranged light chain genes [30]. Phenotypical characterizations of these cell lines revealed reactivity with CD30 and CDw70, and thus these cell lines are phenotypically identical to the EBV+ lymphoblastoid cell lines with both rearranged Ig heavy chains and Ig light chains.

However, CD15 antibodies only stain interdigitating cells after pretreatment of the sections with neuraminidase (Table 3). Such an enzymatic pretreatment of sections is not necessary to label HRS cells. The IRAC antibody proved to be unrestricted in its specificity to interdigitating cells. This antibody also stains macrophages, germinal center cells, and other lymphoid cells. Furthermore, antigens expressed at a high density on interdigitating cells, such as CD1a and S-100, are absent from HRS cells, and conversely, antigens associated with HRS cells, such as CD30, CDw70, and CD25, are consistently missing in IDC (Table 2).

AmJ Pathol1988; 133:211-217. 19. Dallenbach FE, Stein H. Expression of T-Cell-Receptor j3Chain in Reed-Sternberg Cells. Lancet 1989; ii: 828-830. 20. Stein H, Gerdes J, Schwab U, Lemke H, Diehl V, Mason DY, Bartels H, Ziegler A. Evidence for the detection of the normal counterpart of Hodgkin's and Sternberg-Reed cells. Haematol Oncol1983; 1:21-29. 21. Weiss LM, Strickler JG, Warnke RA, Purtilo DT, Sklar J. Epstein-Barr viral DNA in tissues of Hodgkin's disease. Am J Pathol1987; 129:86. 22. Anagnostopoulos I, Herbst H, Niedobitek G, Stein H.

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