Download Antimicrobial drug discovery : emerging strategies by George Tegos, Eleftherios Mylonakis PDF

By George Tegos, Eleftherios Mylonakis

Drug resistance is expanding between various human pathogenic microorganisms equivalent to Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as the most very important medical demanding situations of this century. elevated common know-how and worry of those pathogens capacity there's a starting to be call for for study to take on the specter of multidrug resistance. Documenting the newest learn within the box, this publication discusses present and promising actions to find new antimicrobials in 5 key components: molecular genetics and structures microbiology; artificial, computational chemistry and chemoinformatics; excessive Throughput Screening (HTS); non-vertebrate version hosts; and lightweight- and nano-based applied sciences.

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Extra resources for Antimicrobial drug discovery : emerging strategies

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Bitter, W. M. (2011) Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component. Disease Models and Mechanisms 4, 526–536. A. G. (2010) Energy dose parameters affect antimicrobial photodynamic therapy-mediated eradication of periopathogenic biofilm and planktonic cultures. Photomedicine and Laser Surgery (Suppl. 1), S61–S66. , Douglas, T. and Young, M. (2010) Targeted delivery of a photosensitizer to Aggregatibacter actinomycetemcomitans biofilm.

Biometals 22, 633–648. F. P. (1998) Hospital-acquired candidemia. The attributable mortality and excess length of stay. Archives of Internal Medicine 148, 2642–2645. WHO (2010) Global Tuberculosis Control. World Health Organization Press, Geneva. Wilson, M. and Yianni, C. (1995) Killing of methicillinresistant Staphylococcus aureus by low-power laser light. Journal of Medical Microbiology 42, 62–66. Xavier, J. (2011) Social interaction in synthetic and natural microbial communities. Molecular Systems Biology 7, 483.

Lastly, diseases caused by a known pathogen but attacking new populations, and the toxicity of some of the current compounds (Strohl, 1997), mean there is a continued need for new antibiotics. 3 Evidence for the Decrease in Discovery of New Antibiotics The number of new antibiotics discovered has steadily decreased, as evidenced by the following: 1. There were 120 drug approvals by the US Food and Drug Administration (FDA) in 1996 and 1997 (Ryan, 2003). Due to the movement of the pharmaceutical industry away from natural products, especially antibiotics, the number of drug approvals dropped to 36 in 2004 and then to 20 in 2005 (Mullin, 2006a).

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